• SESSION 2: SICKLE CELL: BOTH A QUALITATIVE AND A QUANTITATIVE TRAIT

11:00 – 11:25 HbAS with sickle complications: a diagnostic challenge
Swee Lay Thein, King’s College London / King’s College Hospital, UK

11:25 – 11:50  Sickle cell trait and renal complications
Claire Sharpe, King’s College London / King’s College Hospital, UK

11:50 – 12:15  Limitations of HbF as a phenotype modifier
Adekunle Adekile, Kuwait University, Kuwait

• SESSION 3: COMPLICATIONS AND MANAGEMENT ISSUES

12:15 – 12:40  Heart and pulmonary vasculature in sickle cell disease
Gerry Coghlan, Royal Free Hospital, UK

12:40 – 14:00 Extended buffet lunch (James Black Centre foyer)

14:00 – 14:30  Stroke prevention: 20 years on
Robert Adams, MUSC Stroke Center, USA

14:30 – 15:00  Extracranial causes of stroke in sickle cell disease
David Rees, King’s College London / King’s College Hospital, UK

15:00 – 15:30  Cognition in sickle cell disease
Fenella Kirkham, UCL Institute of Child Health/ Southampton University Hospital, UK

15:30 – 16:00 Afternoon break (James Black Centre foyer)

• SESSION 4: COMPLICATIONS AND MANAGEMENT ISSUES

16:00 – 16:30  Managing pregnancy in sickle cell disease
Jo Howard, Guys and St Thomas’ Hospital, UK

16:30 – 17:00  Update on blood transfusion in sickle cell disease
Alek Mijovic, King’s College Hospital, UK

17:00 – 17:30 Sexual dysfunction, fertility issues and priapism in sickle cell disease
Nick Watkin, St. George’s Hospital, UK

17:30                  DAY ONE CLOSE

Friday 25  May 2012

08:50 – 09:00 Welcome from Alan McGregor, Campus Dean, King’s Denmark Hill campus

•  SESSION 1 COMPLICATIONS AND MANAGEMENT ISSUES

09:00 – 09:30 Case studies: complications in pregnancy
Emma Drasar, King’s College London / King’s College Hospital, UK

09:30 – 10:05  The many faces of sickle cell pain
Samir Ballas, Thomas Jefferson University, USA

10:05 – 10:35 Bone and joint complications
Marcus Bankes, Guys and St Thomas’ Hospital, UK

10:35 – 11:05  Iron overload
John Porter, University College London, UK

11:05 – 11:35  Mid-morning break (James Black Centre foyer)

• SESSION 2 THE HAEMOLYSIS PARADIGM IN SICKLE CELL DISEASE

11:35 – 12:05  Hemolytic anemia as a mechanism for vasculopathy and pulmonary hypertension in sickle cell disease
Mark Gladwin, University of Pittsburgh Medical Center, USA

12:05 – 12:35  The hyper-hemolysis paradigm from the perspectives of systems biology and evidence based medicine
Robert Hebbel, University of Minnesota, USA

12:35 – 12:55  Discussion

12:55 – 13:55  Buffet lunch (James Black Centre foyer)

• SESSION 3 EVOLVING CONCEPTS AND EMERGING THERAPIES

13:55 – 14:25  Novel aspects of imaging in sickle cell disease
John Wood, Children’s Hospital Los Angeles, USA

14:25 – 14:55  Inflammation and endothelial cell activation as therapeutic targets in sickle cell disease
Fernando Ferreira Costa, UNICAMP, Brazil

14:55 – 15:25  HbF reactivation: a pipeline for epigenetic and targeted therapeutics
Susan Perrine, Boston University School of Medicine, USA

15:25 – 15:55  Sickle cell disease: lessons learned from clinical trials
Abdullah Kutlar, Medical College of Georgia, USA

15:55 – 16:25   Afternoon break (James Black Centre foyer)

• SESSION 4 BONE MARROW TRANSPLANT

16:25 – 16:55  Bone marrow transplant in children
Josu de la Fuente, Imperial College London, UK

16:55 – 17:25  Non-myeloablative allogenic heamtopoietic stem cell transplantation (allo-HSCT) for patients with severe sickle cell disease
John Tisdale, National Institute of Health

17:25   CONFERENCE CLOSE