Paul Frenette is the founding Director and Chair of the Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine at Albert Einstein College of Medicine. His research interests have focused on the stem cell microenvironment and also on vascular biology in sickle cell disease. His laboratory has uncovered the critical role of the sympathetic nervous system in the regulation of hematopoietic stem cell (HSC) egress from their niches, followed by groundbreaking discovery elucidating circadian rhythmicity in HSC release, and the identification of a novel candidate stem cell niche in the bone marrow. His laboratory has also shown that neutrophils were direct participants in the vaso-occlusive episodes that characterize sickle cell disease and defined some of the molecular mechanisms.
Dr. Frenette was elected member of the American Society for Clinical Investigation (2004) and of the Association of American Physicians (2010). He has served on the editorial boards of Blood, the JCI, Stem Cell Report, the Medical Advisory Board of the New York Stem Cell Foundation, as chair of a scientific committee of the American Society of Hematology, and on the Sickle Cell Advisory Council of National Heart, Lung, and Blood Institute and multiple other panels at the NIH. He was recently elected Vice-President of the International Society of Experimental Hematology (ISEH) and will become president of ISEH in 2015.