Sickle cell disease (SCD) is a clinically significant haemoglobinopathy with increasing global incidence. Pre-implantation genetic diagnosis (PGD) for the prevention of the birth of a child affected by SCD is an established, viable treatment option for at risk couples. It could also be used for the prevention and cure of SCD by identifying HLA-matched, disease-free embryos which could become stem cell donors for existing siblings affected by the disease. Potential barriers to uptake of this service need to be investigated to ensure its availability to all couples seeking to avoid having a child affected with SCD.