sugar: the bitter truth transcript

72.000000 397.000000 Td (food? endobj BT stream 0000095371 00000 n 0000188252 00000 n endobj Tj endstream 847 0 obj<> 0000022604 00000 n EMC ET It tasted awful. ) 749 0 obj<> This is ) Tj 0000105270 00000 n EMC He argues that fructose (too much) and fiber (not enough) appear to be cornerstones of the obesity epidemic through their effects on insulin. And this has been shown by numerous investigators now: the small dense LDL is ) Tj EMC endobj 260 0 obj<> stream 72.000000 452.000000 Td 72.000000 686.000000 Td Now glycogen is the storage form of glucose in the liver; ) Tj (liver enzyme marker ALT, alanine aminotransferase, which tells you about fatty liver, and ) Tj endstream (poison. /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw ET endobj 754 0 obj<> Tj 0000062630 00000 n 72.000000 93.000000 Td stream 869 0 obj<> An illustration of a heart shape ; Contact; Jobs; Volunteer; People . stream /P <> BDC They are correct. endstream stream EMC (inflammation through JNK-1, hepatic insulin resistance because of the serine ) Tj So this is it. ) endobj (a book. stream stream 0000133375 00000 n (read a true prophecy you find this book, its not easy to find but if you go find this ) Tj 72.000000 383.000000 Td 452 0 obj<> endobj 72.000000 172.000000 Td ET /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw We thought it might be useful for our readers. 72.000000 720.000000 Td endobj stream 362 0 obj<> 859 0 obj<> 332 0 obj<> 72.000000 564.000000 Td ET EMC (So what's in soft drinks?) EMC endstream /FNT_Courier_Bold 9.090909 Tf 95.000000 Tz 0.000000 Tw endstream And I am going ) Tj This acetyl-CoA and this ethanol and this ) Tj endstream ET ET (Now if you want to say that it's all about diet and exercise, then you have to explain ) Tj ET endstream 225 0 obj<> endstream endstream (Association, he will tell you there is absolutely no association between sugar ) Tj 103 0 obj<> 0000188019 00000 n BT (corn syrup, you can replete your glycogen faster than with glucose alone. So you should be able to cut that way back,) Tj 280 0 obj<> ET 298 0 obj<> ET (Now a little of that glucose is going to fall down here, its going to get metabolize ) Tj ET (What is high fructose corn syrup?) /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw endstream 486 0 obj<> endobj endstream (can of Coke? It's also ) Tj 0000016156 00000 n stream ET BT 0000147097 00000 n This is the thing that ultimately gets fat mechanics going. EMC endobj (This is called de novo meaning new lipogenesis - fat making - this is de novo ) Tj /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw ET 72.000000 676.000000 Td ET 374 0 obj<> 0000029386 00000 n endstream /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw stream endstream /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw (corn syrup and sucrose. /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw 236 0 obj<> So we ) Tj BT stream (you're consuming fat. (weve let it through the addition of fructose for palatability, especially because they ) Tj BT stream endobj ET 0000170244 00000 n EMC /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw endobj /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw Why did it happen? /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw You see the ) Tj That's the guy you don't want to be, because youre going to die of a heart attack. ) /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw endobj EMC BT Therefore you eat more. ) Tj (disease called hypertension. EMC 72.000000 406.000000 Td EMC BT endstream BT EMC 0000007086 00000 n ET /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw It's not about the ) Tj 0000030521 00000 n /P <> BDC (can make it. stream 72.000000 508.000000 Td 0000194132 00000 n (concerned in life you've got two choices its either fat or fart. /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw We talked about 112 pounds of orange juice that the kid down in Salinas ) Tj 478 0 obj<> endstream 242 0 obj<> EMC endstream (single thing that this man said in 1972 is the God's honest truth. 0000116128 00000 n (then activates this transcription factor here - carbohydrate response element binding ) Tj 237 0 obj<> >>/Contents [ 180 0 R 181 0 R 182 0 R 183 0 R 184 0 R 185 0 R 186 0 R 187 0 R 188 0 R 189 0 R 190 0 R 191 0 R 192 0 R 193 0 R 194 0 R 195 0 R 196 0 R 197 0 R 198 0 R 199 0 R 200 0 R 201 0 R 202 0 R 203 0 R 204 0 R 205 0 R 206 0 R 207 0 R 208 0 R 209 0 R 210 0 R 211 0 R 212 0 R 213 0 R 214 0 R 215 0 R 216 0 R 217 0 R 218 0 R 219 0 R 220 0 R 221 0 R 222 0 R 223 0 R 224 0 R 225 0 R 226 0 R 227 0 R 228 0 R 229 0 R 230 0 R 231 0 R 232 0 R 233 0 R 234 0 R 235 0 R 236 0 R ] >> endstream 0000122214 00000 n /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw 49 0 obj<> 0000000109 00000 n 703 0 obj<> ET BT The reason ) Tj ET endstream 0000218024 00000 n endstream stream (45 calories out of the 275, nothing. ET endstream (So here is lab fructose over here, crystalline fructose, and they are starting to put ) Tj (This is the conglomerate of the following different phenomena: obesity, type II diabetes, ) Tj /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw 0000053108 00000 n /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw endobj 72.000000 575.000000 Td EMC (soft drinks, 35% increase in fruit drinks, fruit aids, whatever you want to call them. ) BT endobj 72.000000 209.000000 Td ET EMC 72.000000 604.000000 Td 109 0 obj<> (your insulin levels down which is good for you. (phosphate cant get out of the liver. 66 0 obj<> EMC 72.000000 283.000000 Td BT Question is why? ET stream (discourage consumption for public health reasons. endobj /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw 0000068176 00000 n endstream ET 2. /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw 0000029145 00000 n Tj ET Glucose is the energy of life. /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw Normally that would make leptin and the leptin ) Tj /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw 526 0 obj<> endstream endstream BT ET Anybody here work for ) Tj I ) Tj So how do you make something palatable that has no fat in it? stream endstream ET 95 0 obj<> BT endobj ET Fructose ) Tj /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw BT 72.000000 375.000000 Td endobj endobj So ) Tj stream stream /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw EMC /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw ET 0000102295 00000 n 702 0 obj<> EMC (you think you need more. endstream BT 0000191096 00000 n BT 432 0 obj<> 273 0 obj<> 15 0 obj<> ET (This is what we've done over the last 30 years. ) 72.000000 186.000000 Td EMC And then well go from there and Ill try to explain how this all works. There were people lined up on both sides of the story. 0000218896 00000 n endobj 0000158844 00000 n 72.000000 508.000000 Td /FNT_Courier_Bold 9.090909 Tf 95.000000 Tz 0.000000 Tw Tj 649 0 obj<> >>/Contents [ 591 0 R 592 0 R 593 0 R 594 0 R 595 0 R 596 0 R 597 0 R 598 0 R 599 0 R 600 0 R 601 0 R 602 0 R 603 0 R 604 0 R 605 0 R 606 0 R 607 0 R 608 0 R 609 0 R 610 0 R 611 0 R 612 0 R 613 0 R 614 0 R 615 0 R 616 0 R 617 0 R 618 0 R 619 0 R 620 0 R 621 0 R 622 0 R 623 0 R 624 0 R 625 0 R 626 0 R 627 0 R 628 0 R 629 0 R 630 0 R 631 0 R 632 0 R 633 0 R 634 0 R 635 0 R 636 0 R 637 0 R 638 0 R 639 0 R 640 0 R 641 0 R 642 0 R 643 0 R 644 0 R 645 0 R 646 0 R 647 0 R 648 0 R ] >> EMC endobj 725 0 obj<> ET 464 0 obj<> So this doesn't ) Tj 210 0 obj<> endobj 605 0 obj<> ET endobj 72.000000 227.000000 Td ET 51 0 obj<> Here are the numbers. stream endstream ET (Soft drinks and Type 2 diabetes?) stream 559 0 obj<> endstream (came from Kelly Brownell's group at Yale. ET EMC ET stream stream EMC stream So what do we call it where when you ) Tj endobj 0000039880 00000 n 72.000000 451.000000 Td EMC ET EMC 0000075324 00000 n /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw After all you see anybody on the street, hes a glutton and slough. BT Can you name the seven ) Tj endobj BT /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw What do you think raises your small dense? ) Someday were going to ) Tj BT 0000178962 00000 n Tj So that little Japanese guy with a little hat,) Tj BT (down. Its a mild stimulant, its also a diuretic, makes you pee free water. 72.000000 642.000000 Td endobj /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw 72.000000 318.000000 Td 468 0 obj<> 479 0 obj<> (Okay. Plus there's a new literature that shows the more sugar the ) Tj stream BT Except a one little ) Tj 0000128353 00000 n /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw (hormone. 63 0 obj<> 907 0 obj<> endobj (there's a whole bunch of high fructose corn syrup in the dipping sauce. ) EMC 72.000000 654.000000 Td BT BT 131 0 obj<> endobj endobj (we learned that A led to B. (you can imagine. 0000061485 00000 n (free fatty acids and these free fatty acids will take up residence in the muscle and you ) Tj /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw 851 0 obj<> BT 72.000000 95.000000 Td (all sorts of reasons which are beyond the scope of this lecture today. (you're starving even though your fat cells are generating a signal that says hey, I'm ) Tj By the way, the Chicken McNuggets have a ) Tj stream endstream 0000187776 00000 n ET BT But anyway there's why we use it: it's sweeter. 189 0 obj<> endobj EMC 0000200061 00000 n 72.000000 609.000000 Td endstream ET 0000130926 00000 n ET ET 72.000000 334.000000 Td /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw ET stream EMC 0000070109 00000 n /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw EMC EMC /FNT_Courier_Bold 9.090909 Tf 95.000000 Tz 0.000000 Tw 686 0 obj<> 0000030940 00000 n 72.000000 486.000000 Td (bad. endstream Well, beverage intake - 41% increase in ) Tj 72.000000 250.000000 Td (the liver is with hormones - glucagon or epinephrine. endobj endobj endobj We have carb ) Tj (Now in 1955 after World War II and sugar became plentiful, again it wasnt being rationed,) Tj endstream 0000031183 00000 n endobj What ) Tj endstream ET EMC 577 0 obj<> stream /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw Thats the bad ) Tj 0000083242 00000 n (there's the rub. (the same. 72.000000 497.000000 Td stream EMC 25% of the adolescents today consume at ) Tj 72.000000 264.000000 Td 72.000000 118.000000 Td endstream 0000036121 00000 n 99 0 obj<> endstream endobj /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw 72.000000 687.000000 Td Now it is often said that obesity is the ultimate interaction between genetics and environment. Because it burns calories. BT BT 72.000000 664.000000 Td EMC ET EMC (The Paleolithic diet - basically if you read everything as it came out of the ground off ) Tj EMC ET (right because of that VLDL coming from glucose. I mean, all these countries who have adopted our diet all suffer now from the same problem, and were going to get even further in a minute. endstream 873 0 obj<> He argues that fructose (too much) and fiber (not enough) appear to be cornerstones of the obesity epidemic through their effects on insulin. 0000197675 00000 n 72.000000 687.000000 Td EMC BT So theres something wrong with our biochemical negative feedback system that normally controls energy balance. endstream endobj (And here is sucrose. /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw endobj ( It's actually sweeter. It's how they are not the same.) 445 0 obj<> /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw EMC (that description but not with the prevention of chronic diseases even though its own ) Tj This was my daughter when she was in second ) Tj stream 0000129005 00000 n 72.000000 519.000000 Td 72.000000 319.000000 Td stream 72.000000 462.000000 Td EMC /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw stream stream EMC BT 72.000000 553.000000 Td stream 72.000000 454.000000 Td /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw BT 0000177073 00000 n 243 0 obj<> endobj /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw 72.000000 108.000000 Td They make the stuff that lets you live called ATP - ATP adenosine ) Tj endobj 145 0 obj<> EMC /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw Here is the London price doing the same thing and ) Tj ET endstream So this is one of the reasons why alcohol is bad. (poison. ) Well whats in Coke? ET EMC (thought process, you know by some very smart nutritionists etc. A calorie is not a calorie, and the ) Tj 72.000000 175.000000 Td BT Tj 72.000000 286.000000 Td endobj 414 0 obj<> 114 0 obj<> /FNT_Courier_Bold 9.090909 Tf 95.000000 Tz 0.000000 Tw /FNT_Courier 9.090909 Tf 95.000000 Tz 0.000000 Tw So here's the dyslipidemia of fructose consumption, we are not done. )
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